09:00 – 09:30

09:30 - 10:00

Brian Johnstone (US)
Lifetime Achievement

Prof Gerjo Van Osch (NL)
Revealing the secrets of the zone of calcified cartilage

10:00 – 10:45

Coffee Break

10:45 – 11:15

11:15 - 11:45

11:45 - 12:00

12:00 - 12:15

Session 2: Clinical Developments
Chairs: Sonja Häckel & Ali Mobasheri

Xudong Joshua Li (US)
A Novel Platform for Investigating Neuroimmune Interactions in Degenerative Disc Disease

Martin Englund (Sweden)
Osteoarthritis – an evolutionary mismatch disease?

Temporal proteomic profiling of PTOA identifies the optimal therapeutic window for anti-inflammatory cell therapy.
R Lev-Gur,N More, N Mahmoudi,J Sheyn,D Roell,W Tawackoli, D Sheyn

A personalized multi-scale modeling workflow to estimate OA-related cartilage biomarkers.
A Abedi, A Elahi, Y Zhang, A Esrafilian, M Willems, BA.Killen, I Jonkers

12:15 – 15:00

Lunch (not provided)

15:00 – 15:30

15:30 - 16:00

16:00 - 16:15

16:15 - 17:00

Session 3: Tissue Engineering and Regenerative Medicine
Chairs: Gerjo van Osch & Katrin Wendrich

Catherine Le Visage (France)
Biofabrication of the intervertebral disc: progress and remaining challenges

Julian Jones (UK)
3D printed “Bouncy Bioglass” can regenerate articular cartilage focal defects

A nasal chondrocyte-based inflammation resistant therapy for osteoarthritis.
A Damle, D Mock, B Dasen, K Sovdagarova, L Sauteur, SR Roig Merino, T Welting, A Garcia-Garcia, P Ismailidis, F Imhoff, I Martin, A Mainardi, A Barbero

Biomimetic Composite Hydrogel using Silk Fibres, Hyaluronic Acid, and Collagen type II for Nucleus Pulposus Regeneration
A Kumar, PT Rahvar, A Bouduban, M Wöltje, B Gantenbein

16:30 – 17:00

Coffee Break

17:00 – 17:30

17:30 - 18:00

18:00 - 18:15

18:15 - 18:30

Session 4: Preclinical and Clinical Research
Chairs: Jaqueline Lourdes & Jun Dong

Chris Little (AUS)
Joint injury: new insights from animal models on injury risk and long-term consequences

Giuseppe Filardo (Switzerland)
Cartilage regeneration and joint preservation: A challenging translational journey to the clinical practice

The immediate postoperative joint milieu is predominantly alkaline under normal and staphylococcal septic conditions.
TP Schaer, OM Swiber, RM Butler, A Winslow, M Seraydarian, C Durst, CM Snyder, AF Chen, NJ Hickok

Chronic stress-induced spatiotemporal alterations in corticosterone.
G Rösch, M Pfeiffer, PL Tsai, M Gold, F Zaucke, D Slattery, Z Jenei-Lanzl

18:30 – 20:00

Poster Reception

008:30 – 09:00

09:00 - 09:30

09:30 - 09:45

09:45 - 10:00

10:00 - 10:15

10:15 - 10:30

Session 5: Cells in Orthopaedics
Chairs: Benjamin Gantenbein & Fengjin Guo

Rui Yue (China)
Identification of novel skeletal stem/progenitor cells in the perichondrium

Makarand Risbud (US)
Central role of pyrophosphate metabolism in spine health

Extracellular vesicles from spontaneously calcifying chondrocytes stimulate chondrocyte and matrix calcification
A Schwab, C Schneider, S Gylstorf, C Göttsch, A Halm-Pozniak. CH Lohmann, J Bertrand

Unlocking CD44+ intervertebral disc cells in homeostasis and degeneration for therapeutic targets in discogenic pain
S Pilão, AM Martins,J Caldeira, L Teixeira, RM Gonçalves

Mechanically preconditioned synovial mesenchymal stem cells organoid exosomes for osteoarthritis repair
C Li, F Yuan, T Zhang, J Zhou, H Lyu

Mesenchymal stromal cell spheroid-loaded microscaffolds for intervertebral disc repair
M Muerner, RV Balasubramanian, J Fernández-Pérez, A Ovsianikov, S Grad

10:30 – 11:00

Coffee Break

11:00 – 11:30

11:30 - 12:00

12:00 - 12:15

12:15 - 12:30

12:30 - 12:45

12:45 - 13:00

Session 6: Mechanobiology and Modeling
Chairs: Mario Rothbauer & Maja Schlittler

Martin Knight (UK)
Organ-on-a-chip models of inflammatory joint disease

Jérôme Noailly (Spain)
From people to molecules: In silico insights for precision health in spine and synovial joints

Pericellular Matrix Restoration Enhances Resistance of Chondrocytes to Inflammatory and Mechanical Stress.
H Meng, MJ Stoddart, S Grad, Z Li

Exploring TRPV4 mechanosensitivity to substrate stiffness and mechanical loading in annulus fibrosus.
J Hasler, K Wuertz-Kozak

Human disc-on-a-chip: modelling human intervertebral disc degeneration via microfluidic and hydrogel-based system.
I Zulkiflee, Z Razak, H Revill, A Pandit, ILM Isa

The “village-in-a-dish” approach as an innovative cellular model for investigating variability in response to loading in chondrogenic cells.
A Bertocci, S Costa, A Flier, L You, P Chiafele, M Ghazvini, H Ray-Jones G van Osch, MP Chien, J de Pinho Gonçalves, J van Meurs, R Narcisi

13:00 – 18:00

Free Afternoon (pre-order lunch)
2 Hiking options. More information to follow.

18:00 – 00:00

Congress Dinner
Walserhuus Sertig
Meeting point 17:50 Entrance Congress Center, Promenade.

08:30 – 09:00

09:00 - 09:30

09:30 - 09:45

09:45 - 10:00

Session 7: Tissue Cross-talk
Chairs: Brian Johnstone & Fatemeh Safari

Rachel E. Miller (US)
Neuroplasticity in osteoarthritis

Jiao Jiao Li (Australia)
The potential of MSCs and MSC-EVs a new therapeutics for osteoarthritis

A neurovascular disc system to study the role of endothelial cells in nociceptive axonal growth.
J Ma, J Müller, T Serra, S Grad

Intradiscal propionic acid levels in chronic low back pain patients (CLBP) with Modic type 1 changes (MC1) are associated with systemic immune cell activation.
J Devan, J Zhou, P Wu, N Bonnheim, C O’Neill, JC Lotz, TM Link, AJ Fields, S Dudli

10:00 – 10:30

Coffee Break

10:30 – 11:00

11:00 - 11:30

11:30 - 11:45

11:45 - 12:00

Session 8: ORS Spine Section Session
Chair: Mauro Alini & Marcia Mürner

Marianna Tryfonidou (Netherland)
Notochordal cells lead the way to regeneration

Nam Vo (US)
Intervertebral disc lactate: waste byproduct or valuable metabolite?

High-resolution spatial transcriptomic and proteomic mapping of the developing human intervertebral disc.
CT Dube, EM Oldfield, SM Baker, M Buckley, R Jennings, JA Hoyland, SM Richardson

Direct In Vivo capture of the nucleus pulposus secretome.
A Upadhyay, G Belen, CL Dahia

12:00 – 13:00

Lunch (pre-ordered lunch)

13:00 – 13:30

13:30 - 14:00

14:00 - 14:15

14:15 - 14:30

Session 9: EU Consortiums - SinPain, OstaSkills and NetwOArk
Chair: Andrea Barbero & Laura Mecchi

Zhen Li (Switzerland)
Advancing osteoarthritis therapy: In Vitro and Ex Vivo modeling in bioreactor platforms

Tim Welting (Netherland)
Exploring the bioactivity of synovial fluid in osteoarthritis as a vector for intra-joint biomolecular cross-talk

Dynamic compression strain drives chondrogenic transcriptional fate through actin cytoskeleton dynamics, TGF-β/SMAD signalling and YAP1 translocation.
MC Cordeiro, AG Guex, JK Wychowaniec, A Barbero, MJ Stoddart

Objective imaging biomarkers for knee OA: A data-driven view of cartilage degeneration.
FK Ciliberti, I Maruotto,, Hr Jónsson, P Gargiulo

14:30 – 15:00

15:00 - 15:15

15:15 - 15:30

Session 10: Drug and Gene delivery
Chair: Chris Evans & Marta Santolini

Ambika G Bajpayee (US)
Charge-driven nucleic acid delivery to cartilage

Protective effects of IL-1Ra gene therapy on intervertebral disc degeneration: In Vitro and In Vivo findings in beagle dogs.
SA Kamali, C Voskamp, LT Laagland, A Eversdijk, M Teunissen, S Plomp, A Tellegen, G Sponder, BP Meij, K Guse, S Plutizki, MA Tryfonidou

Ex Vivo exploration of PCRX-201 in human OA joint tissues.
G McDermott, D.Swift, M Kim, D Jackson, JM Wilkinson, CL Le Maitre

15:30 – 16:00

Awards & Closing
Sibylle Grad (CH)
Student awards and conference closing