08:30 – 08:45

Esther Wehrle (CH)
AO Research Institute

08:45 – 09:00

Sophie Verrier (CH)
Welcome to Davos

10:30 – 11:00

David Hoey (IE)
Targeting mechanosignalling to modulate bone repair

11:00 – 11:30

Andrew Pitsillides (UK)
Bone mechanoadaptation – local to whole-organ considerations

11:30 – 12:00

Markus Windolf (CH)
From basic research to patient benefit – the journey of the biphasic plate

12:00 – 12:15

M Keiser, S Preiss, SJ Ferguson, VA Stadelmann
Subchondral bone migrates into trabecular bone in response to direct bone-on-bone contact wear in patients with severe knee osteoarthritis

12:15 – 12:30

P Füllemann, T Jörimann, M Stoddart, R Matthys, S Verrier
Mechanical strain triggers naïve MSCs in vitro differentiation towards hypertrophic chondrocytes

15:00 – 15:30

Vaida Glatt (US)
Biomimetic hematoma to enhance bone healing: current status and future clinical implications

15:30 – 16:00

Louis WH Cheung (HK)
External biomechanical stimulation as an approach to stimulate fracture healing

16:00 – 16:30

Enrique Gomez-Barrena (ES)
Clinical trials on expanded MSCs for bone regeneration

16:30 – 17:00

Shukry James Habib (CH)
A novel bandage for bone repair

17:00 – 17:30

Andrea Banfi (CH)
The interplay of angiogenesis and osteogenesis for bone regeneration

17:30 – 17:45

M Schröder, L Gens, L Bernhard, D Ahrens, D Gehweiler, S Zeitler, M Stoddart, E Wehrle
Effects of low dose BMP-2 on cytokine levels during fracture healing in a femur segmental defect in rats

17:45 – 18:00

R Randriantsilefisoa, G Miklosic, EI Bektas, M D'Este
Filling the gaps: dynamic alginate-hydroxyapatite composite for bone tissue regeneration

18:00 – 18:15

SW Verbruggen, J Nolan, MP Duffy, OMT Pearce, CR Jacobs, MM Knight
A TGF-β cross-talk mechanism, in both breast and prostate cancer, which disrupts osteocyte primary cilia-mediated regulation of bone metastases

18:15 – 18:30

M Haffner-Luntzer, B Weber, K Morioka, I Lackner, V Fischer, CS Bahney,              A Ignatius, M Kalbitz, R Marcucio, T Miclau
Multi-organ crosstalk during bone fracture healing - interplay between brain trauma, bone and the immune system

08:30 – 09:00

Kurt Hankenson (US)
Utilizing single cell RNA sequencing to study poor fracture healing

09:00 – 09:30

Esther Wehrle (CH)
Individualized omics-based preclinical models for bone healing

09:30 – 09:45

MR Iaquinta, R De Pace, A D’Agostino, L Trevisiol, F Lonardi, M Bersani, M Tognon, F Martini, E Mazzoni
Release of stem cell paracrine factors, and bone regrowth in patients, induced by composite scaffold

09:45 – 10:00

M Stewart, J Nguyen- Edquilang
Transient TGF- b exposure activates BMP-dependent periosteal osteogenesis

10:00 – 10:15

J Barcik, M Schröder, D Arens, L Gens, D Mischler, D Gehweiler, S Zeiter, P Varga, M Stoddart, E Wehrle
Longitudinal monitoring of healing progression via in vivo stiffness measurements in a mouse femur defect model

10:15 – 10:30

M van Griensven, R Groven, ER Balmayor, M Poeze, TJ Blokhuis
miRNAs play a pivotal role in fracture healing

11:00 – 11:30

Elizabeth R. Balmayor (DE)
cmRNA and its delivery for bone regeneration

11:30 – 12:00

Yu-Chen (Andy) Hu (TW)
Intelligent CRISPR design for bone regeneration

12:00 – 12:15

EB McGlinch, JA Panos, MJ Coenen, MA Barry, CH Evans
Vector engineering and development for osseous nonunions

12:15 – 12:30

M Wiesli, S Kiderlen, A González-Vásquez, K Maniura, M Rottmar, W Lackington
Improving mineralization in a novel fracture hematoma model via delivery of IL-10 and BMP-7

12:30 – 12:45

RE de la Vega, MJ Coenen, GP Hawse, JA Panos, A Atasoy-Zeybek, CV Nagelli, CH Evans
Feasibility of use of a non-osteogenic, genetically modified cell line for large bone regeneration in a rat femoral segmental defect model

12:45 – 13:00

D Cadoux-Hudson, J Kanczler, K Dexter, S Tilley, N Evans
Demonstrating microbubble perfusion and cavitation within a murine critical calvarial defect

08:30 – 09:00

Julian Antoniac (RO)
Biodegradable magnesium alloys for trauma implants

09:00 – 09:15

FE Weber
3D-printed bone substitutes for osteoconduction and bone augmentation: When architecture meets biology

09:15 – 09:30

J Vecstaudza, CM Sprecher, M D’Este, J Locs, E Della Bella
Osteoclastic resorption of calcium phosphate-based materials is influenced by the crystallization pathway

09:30 – 09:45

D Van der Heide, LP Hatt, E Della Bella, H Yuan, F De Groot-Barrère, MJ Stoddart, M D'Este
3D printed composite resembling natural bone by combining hyaluronan, collagen and calcium phosphate to promote bone regeneration

09:45-10:00

L Sicard, S Maillard, DM Akoa, C Chaussain, T Coradin
Chitosan-modified dense collagen hydrogels loaded with anti-sclerostin antibodies as biomaterials for critical size calvaria defect repair

10:00 – 10:15

M Laubach, B Herath, N Bock, S Suresh, S Saifzadeh, BL Dargaville, S Cometta,
V Schemenz, J McGovern, ML Wille, FM Savi, DW Hutmacher
In vivo study of 3D-printed polycaprolactone-hydroxyapatite scaffolds with Voronoi design to advance the concept of scaffold-guided bone regeneration

10:45 – 11:15

Anita Ignatius (DE)
Mast cells - Crucial modulators in osteoporotic fracture healing

11:15 – 11:45

Rik Osinga (CH)
Role of soft tissue in fracture-related infection (FRI) and periprosthetic joint infection (PJI)

11:45 – 12:00

A Pylostomou, R Tognato, JK Wychowaniec, M D'Este, JR Weiser, T Serra, D Loca, A Vernengo
Thermosensitive support baths promoting aligned anisotropic stem cell clustering for endochondral bone tissue engineering

12:00 – 12:15

MEA Tschaffon-Müller, E Kempter, MR Kuhn, F Gebhard, M Kalbitz, K Schütze,
H Gündel, N Kaleck, K Weimer, A Ignatius, SO Reber, M Haffner-Luntzer
Chronic psychosocial stress disturbs fracture healing via catecholamies produced by immune cells

14:00 – 14:30

Anja Hauser (DE)
Analyzing bone regeneration in time and space: novel approaches for multi-modal, multi-dimensional imaging

14:30 – 15:00

Matteo Moretti (CH)
Engineering 3D human multicellular bone in vitro models as anti-tumor drug screening systems

15:00 – 15:15

I Toillon, S Ferrari, M Gerbaix
Alterations of bone microarchitecture and bone fragility in a type 1 diabetes mouse model (akita mice)

15:15 – 15:30

M Milošević, I Banićević, N Jaćimović, M Miola, F Baino, E Verné, J Stojkovska, B Obradović
Biomimetic alginate-based scaffolds with bioactive glass particles as a relevant in vitro model of bone tissue

15:30 – 15:45

I Banicevic, M Milosevic, J Petrović, K Menshikh, M Milivojevic, M Stevanovic,
R Jankovic, A Cochis, J Stojkovska, L Rimondini, B Obradovic
A 3D cell culture model mimicking pathological and physiological conditions in bone

15:45 – 16:00

LP Hatt, AR Armiento, MJ Stoddart
β-TCP from 3D-printed scaffold can act as an effective phosphate source during the osteogenic differentiation of human mesenchymal stromal cell

16:00 – 16:30

Brett D Crist (US) Berton Rahn Research Award winner 2023
RIA versus BMC as orthobiologic augments to allografts

16:30 – 17:00

Martin Stoddart (CH)          
Students awards and conference closing