ARI Orthopaedics Conference
ARI Orthopaedics, Science with Open Discussion

2023 eCM21: Bone and Fracture Repair
10th – 12th July 2023, Congress Center, Davos, Switzerland

Monday, July 10th


08:30 – 08:45

Esther Wehrle (CH)
AO Research Institute

08:45 – 09:00

Sophie Verrier (CH)
Welcome to Davos

Session 1: Opening Session: New clinical developments
Chair: Geoff Richards

09:00 – 09:30

Hamish Simpson (UK)
The non-union timeline: when is the fate of a fracture decided?

09:30 – 10:00

Peter Giannoudis (UK)
Stem cells for bone repair: a clinical perspective


10:00 – 10:30 Coffee Break

Session 2: Mechanobiology
Chair: Martin Stoddart & Kurt Hankenson

10:30 – 11:00

David Hoey (IE)
Targeting mechanosignalling to modulate bone repair

11:00 – 11:30

Andrew Pitsillides (UK)
Bone mechanoadaptation – local to whole-organ considerations

11:30 – 12:00

Markus Windolf (CH)
From basic research to patient benefit – the journey of the biphasic plate

12:00 – 12:15

M Keiser, S Preiss, SJ Ferguson, VA Stadelmann
Subchondral bone migrates into trabecular bone in response to direct bone-on-bone contact wear in patients with severe knee osteoarthritis

12:15 – 12:30

P Füllemann, T Jörimann, M Stoddart, R Matthys, S Verrier
Mechanical strain triggers naïve MSCs in vitro differentiation towards hypertrophic chondrocytes


12:30 – 15:00 Lunch (Lunch not provided)


Session 3: ISFR Joint Session Translational fracture healing research from bench to bedside
Hamish Simpson & Elizabeth Rosado Balmayor

15:00 – 15:30

Vaida Glatt (US)
Biomimetic hematoma to enhance bone healing: current status and future clinical implications

15:30 – 16:00

Louis WH Cheung (HK)
External biomechanical stimulation as an approach to stimulate fracture healing

16:00 – 16:30

Enrique Gomez-Barrena (ES)
Clinical trials on expanded MSCs for bone regeneration

Session 4: Innervation, immunology and angiogenesis
Chair: Sophie Verrier & Maria Schröder

16:30 – 17:00

Shukry James Habib (CH)
A novel bandage for bone repair

17:00 – 17:30

Andrea Banfi (CH)
The interplay of angiogenesis and osteogenesis for bone regeneration

17:30 – 17:45

M Schröder, L Gens, L Bernhard, D Ahrens, D Gehweiler, S Zeitler, M Stoddart, E Wehrle
Effects of low dose BMP-2 on cytokine levels during fracture healing in a femur segmental defect in rats

17:45 – 18:00

R Randriantsilefisoa, G Miklosic, EI Bektas, M D'Este
Filling the gaps: dynamic alginate-hydroxyapatite composite for bone tissue regeneration

18:00 – 18:15

SW Verbruggen, J Nolan, MP Duffy, OMT Pearce, CR Jacobs, MM Knight
A TGF-β cross-talk mechanism, in both breast and prostate cancer, which disrupts osteocyte primary cilia-mediated regulation of bone metastases

18:15 – 18:30

M Haffner-Luntzer, B Weber, K Morioka, I Lackner, V Fischer, CS Bahney,              A Ignatius, M Kalbitz, R Marcucio, T Miclau
Multi-organ crosstalk during bone fracture healing - interplay between brain trauma, bone and the immune system

18:30 – 20:00 Poster session (Drinks & Snacks)


Tuesday, July 11th

Session 5: Markers and Omics
Chair: Esther Wehrle & Anja Hauser

08:30 – 09:00

Kurt Hankenson (US)
Utilizing single cell RNA sequencing to study poor fracture healing

09:00 – 09:30

Esther Wehrle (CH)
Individualized omics-based preclinical models for bone healing

09:30 – 09:45

MR Iaquinta, R De Pace, A D’Agostino, L Trevisiol, F Lonardi, M Bersani, M Tognon, F Martini, E Mazzoni
Release of stem cell paracrine factors, and bone regrowth in patients, induced by composite scaffold

09:45 – 10:00

M Stewart, J Nguyen- Edquilang
Transient TGF- b exposure activates BMP-dependent periosteal osteogenesis

10:00 – 10:15

J Barcik, M Schröder, D Arens, L Gens, D Mischler, D Gehweiler, S Zeiter, P Varga, M Stoddart, E Wehrle
Longitudinal monitoring of healing progression via in vivo stiffness measurements in a mouse femur defect model

10:15 – 10:30

M van Griensven, R Groven, ER Balmayor, M Poeze, TJ Blokhuis
miRNAs play a pivotal role in fracture healing

10:30 – 11:00 Coffee Break

Session 6: Cell, Drug and Gene Delivery
Chair: Elena della Bella & Fatemeh Safari

11:00 – 11:30

Elizabeth R. Balmayor (DE)
cmRNA and its delivery for bone regeneration

11:30 – 12:00

Yu-Chen (Andy) Hu (TW)
Intelligent CRISPR design for bone regeneration

12:00 – 12:15

EB McGlinch, JA Panos, MJ Coenen, MA Barry, CH Evans
Vector engineering and development for osseous nonunions

12:15 – 12:30

M Wiesli, S Kiderlen, A González-Vásquez, K Maniura, M Rottmar, W Lackington
Improving mineralization in a novel fracture hematoma model via delivery of IL-10 and BMP-7

12:30 – 12:45

RE de la Vega, MJ Coenen, GP Hawse, JA Panos, A Atasoy-Zeybek, CV Nagelli, CH Evans
Feasibility of use of a non-osteogenic, genetically modified cell line for large bone regeneration in a rat femoral segmental defect model

12:45 – 13:00

D Cadoux-Hudson, J Kanczler, K Dexter, S Tilley, N Evans
Demonstrating microbubble perfusion and cavitation within a murine critical calvarial defect


Group Photo, Free afternoon & eCM walk

Lunch (Lunch not provided)

18:00 Dinner at Walserhuus Sertig


Wednesday, July 12th

Session 7: Implants and Materials
Chair: Matteo D'Este & Rotsiniaina Randriantsilefisoa

08:30 – 09:00

Julian Antoniac (RO)
Biodegradable magnesium alloys for trauma implants

09:00 – 09:15

FE Weber
3D-printed bone substitutes for osteoconduction and bone augmentation: When architecture meets biology

09:15 – 09:30

J Vecstaudza, CM Sprecher, M D’Este, J Locs, E Della Bella
Osteoclastic resorption of calcium phosphate-based materials is influenced by the crystallization pathway

09:30 – 09:45

D Van der Heide, LP Hatt, E Della Bella, H Yuan, F De Groot-Barrère, MJ Stoddart, M D'Este
3D printed composite resembling natural bone by combining hyaluronan, collagen and calcium phosphate to promote bone regeneration


L Sicard, S Maillard, DM Akoa, C Chaussain, T Coradin
Chitosan-modified dense collagen hydrogels loaded with anti-sclerostin antibodies as biomaterials for critical size calvaria defect repair

10:00 – 10:15

M Laubach, B Herath, N Bock, S Suresh, S Saifzadeh, BL Dargaville, S Cometta,
V Schemenz, J McGovern, ML Wille, FM Savi, DW Hutmacher
In vivo study of 3D-printed polycaprolactone-hydroxyapatite scaffolds with Voronoi design to advance the concept of scaffold-guided bone regeneration

10:15 – 10:45 Coffee Break

Session 8: Fracture repair- more than just bone
Chair: Chris Evans & Ezgi Bektas

10:45 – 11:15

Anita Ignatius (DE)
Mast cells - Crucial modulators in osteoporotic fracture healing

11:15 – 11:45

Rik Osinga (CH)
Role of soft tissue in fracture-related infection (FRI) and periprosthetic joint infection (PJI)

11:45 – 12:00

A Pylostomou, R Tognato, JK Wychowaniec, M D'Este, JR Weiser, T Serra, D Loca, A Vernengo
Thermosensitive support baths promoting aligned anisotropic stem cell clustering for endochondral bone tissue engineering

12:00 – 12:15

MEA Tschaffon-Müller, E Kempter, MR Kuhn, F Gebhard, M Kalbitz, K Schütze,
H Gündel, N Kaleck, K Weimer, A Ignatius, SO Reber, M Haffner-Luntzer
Chronic psychosocial stress disturbs fracture healing via catecholamies produced by immune cells

12:15 – 14:00 Lunch (Lunch not provided)

Session 9: Preclinical models and ex vivo alternatives
Chair: Anita Ignatius & Melanie Haffner - Luntzer

14:00 – 14:30

Anja Hauser (DE)
Analyzing bone regeneration in time and space: novel approaches for multi-modal, multi-dimensional imaging

14:30 – 15:00

Matteo Moretti (CH)
Engineering 3D human multicellular bone in vitro models as anti-tumor drug screening systems

15:00 – 15:15

I Toillon, S Ferrari, M Gerbaix
Alterations of bone microarchitecture and bone fragility in a type 1 diabetes mouse model (akita mice)

15:15 – 15:30

M Milošević, I Banićević, N Jaćimović, M Miola, F Baino, E Verné, J Stojkovska, B Obradović
Biomimetic alginate-based scaffolds with bioactive glass particles as a relevant in vitro model of bone tissue

15:30 – 15:45

I Banicevic, M Milosevic, J Petrović, K Menshikh, M Milivojevic, M Stevanovic,
R Jankovic, A Cochis, J Stojkovska, L Rimondini, B Obradovic
A 3D cell culture model mimicking pathological and physiological conditions in bone

15:45 – 16:00

LP Hatt, AR Armiento, MJ Stoddart
β-TCP from 3D-printed scaffold can act as an effective phosphate source during the osteogenic differentiation of human mesenchymal stromal cell

Awards and conference closing

16:00 – 16:30

Brett D Crist (US) Berton Rahn Research Award winner 2023
RIA versus BMC as orthobiologic augments to allografts

16:30 – 17:00

Martin Stoddart (CH)          
Students awards and conference closing


We advise all presenters to look at the TIPS FOR TALKS (548 kB) presentation and read these guidelines (39kB) before starting to prepare their talks. Science is in the detail. It is the lifeblood of science to discuss.

All invited talks are 20 minutes (20-30 slides) to allow 10 minutes discussion per talk.
All submitted talks are 10 minutes (10-15 slides) to allow 5 minutes discussion per talk.

Chairpersons will cut people off who try to use this time for their talks!
Please bring a copy of your talk on CD or USB stick to give to Presentation Support, Sunday morning at Registration.

Paper Submission
We invite all keynote speakers to submit a paper (either original research report, original review*or original tutorial*) to the European Cells & Materials (eCM) online 'Open & Free Access' journal.*NOTE: We define a REVIEW PAPER as a paper which includes an extended literature review and complete bibliography (including authors' own work), and can also emphasise authors' new unpublished findings and in an extended discussion puts the topic in proper perspective. A review can also be based on a complete bibliography of an author's own work over several years in relation to others. A TUTORIAL PAPER contains an organised comprehensive review of all relevant published material as for a teaching lecture.